PLOD2 Mouse Monoclonal Antibody [Clone ID: LBI6D1]
Product Specifications
Background
The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Synonyms
BRKS2; LH2; TLH
Gene Name
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Gene ID
5352
UniProt
O00469
Conjugation
Unconjugated
Related Pathways
Lysine degradation
Field of Research
Lysine degradation
Concentration
1 mg/ml
Dilution
WB 1:2000
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
PLOD2
Overview
PLOD2 mouse monoclonal antibody, clone LBI6D1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=5352
Uniprot URL
https://www.uniprot.org/uniprot/O00469
Curated Selection
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