FEN1 Mouse Monoclonal Antibody [Clone ID: LBI3A8]
Product Specifications
Background
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]
Synonyms
FEN-1; MF1; RAD2
Gene Name
Flap structure-specific endonuclease 1
Gene ID
2237
UniProt
P39748
Conjugation
Unconjugated
Related Pathways
Base excision repair, DNA replication, Non-homologous end-joining
Field of Research
Base excision repair, DNA replication, Non-homologous end-joining
Concentration
1 mg/ml
Dilution
WB 1:2000, IHC 1:150
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, Stem cell - Pluripotency
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
FEN1
Overview
FEN1 mouse monoclonal antibody, clone LBI3A8
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=2237
Uniprot URL
https://www.uniprot.org/uniprot/P39748
Curated Selection
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