RASGRP3 Mouse Monoclonal Antibody [Clone ID: LBI2C11]

Product Specifications

Background

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RASGRP3, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]) . [supplied by OMIM, Mar 2008]

Overview

RASGRP3 mouse monoclonal antibody, clone LBI2C11

Synonyms

GRP3

Gene Name

RAS guanyl releasing protein 3

Gene ID

25780

UniProt

Q8IV61

Conjugation

Unconjugated

Related Pathways

B cell receptor signaling pathway, MAPK signaling pathway

Field of Research

B cell receptor signaling pathway, MAPK signaling pathway

Concentration

1 mg/ml

Dilution

WB 1:2000, IHC 1:150

Form

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.