RRM1 Mouse Monoclonal Antibody [Clone ID: LBI5G5]
Product Specifications
Background
This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. [provided by RefSeq, Jul 2008]
Synonyms
R1; RIR1; RR1
Gene Name
Ribonucleotide reductase catalytic subunit M1
Gene ID
6240
UniProt
P23921
Conjugation
Unconjugated
Related Pathways
Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism
Field of Research
Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism
Concentration
1 mg/ml
Dilution
WB 1:2000, IHC 1:150
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
RRM1
Overview
RRM1 mouse monoclonal antibody, clone LBI5G5
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=6240
Uniprot URL
https://www.uniprot.org/uniprot/P23921
Curated Selection
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