P18 INK4c (CDKN2C) Mouse Monoclonal Antibody [Clone ID: LBI2D7]
Product Specifications
Background
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]
Synonyms
INK4C; p18; p18-INK4C
Gene Name
Cyclin-dependent kinase inhibitor 2C
Gene ID
1031
UniProt
P42773
Conjugation
Unconjugated
Related Pathways
Cell cycle
Field of Research
Cell cycle
Concentration
1 mg/ml
Dilution
WB 1:2000
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
CDKN2C
Overview
CDKN2C (p18 INK4c) mouse monoclonal antibody, clone LBI2D7
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=1031
Uniprot URL
https://www.uniprot.org/uniprot/P42773
Curated Selection
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