P Glycoprotein (ABCB1) Mouse Monoclonal Antibody [Clone ID: LBI2C7]
Product Specifications
Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
Synonyms
ABC20; CD243; CLCS; GP170; MDR1; p-170; P-GP; PGY1
Gene Name
ATP binding cassette subfamily B member 1
Gene ID
5243
UniProt
P08183
Conjugation
Unconjugated
Related Pathways
ABC transporters
Field of Research
ABC transporters
Concentration
1 mg/ml
Dilution
WB 1:1000~2000, IHC 1:150
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
ABCB1
Overview
ABCB1 mouse monoclonal antibody, clone LBI2C7
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=5243
Uniprot URL
https://www.uniprot.org/uniprot/P08183
Curated Selection
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