PCNA Mouse Monoclonal Antibody [Clone ID: LBI2G7]

Product Specifications

Background

The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]

Overview

Mouse monoclonal anti-PCNA antibody, clone 2G7, Loading, clone LBI2G7

Synonyms

ATLD2

Gene Name

Proliferating cell nuclear antigen

Gene ID

5111

UniProt

P12004

Conjugation

Unconjugated

Related Pathways

Base excision repair, Cell cycle, DNA replication, Mismatch repair, Nucleotide excision repair

Field of Research

Base excision repair, Cell cycle, DNA replication, Mismatch repair, Nucleotide excision repair

Concentration

1 mg/ml

Dilution

WB 1:2000, IF 1:50

Form

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome, Stem cell - Pluripotency

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.