ON 146040

ON 146040 is a potent PI3Kα and PI3Kδ (IC50≈14 and 20 nM, respectively) inhibitor. ON 146040 also inhibits Abl1 (IC50<150 nM).

Bcr-Abl; PI3K

Reference compound

PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK

Cancer

https://www.medchemexpress.com/on-146040.html

95.05

DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)

CN(CC1)CCN1C(C=C2)=CC=C2NC3=NC(S/C(C(N4)=O)=C\C5=CC=C([N+]([O-])=O)C=C5)=C4C=N3

489.55

[1]Targeting oncogenic STAT3 and STAT5 signaling with on 146040, a small molecule inhibitor of PI3K α/δ and BCR-ABL.

Room Temperature

4°C (Powder, protect from light)

http://file.medchemexpress.com/batch_PDF/HY-12338/ON-146040-DataSheet-MedChemExpress.pdf

http://file.medchemexpress.com/batch_PDF/HY-12338/ON-146040-SDS-MedChemExpress.pdf

No Development Reported

1404231-34-0