ON 146040
Product Specifications
UNSPSC Description
ON 146040 is a potent PI3Kα and PI3Kδ (IC50≈14 and 20 nM, respectively) inhibitor. ON 146040 also inhibits Abl1 (IC50<150 nM).
Target Antigen
Bcr-Abl; PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/on-146040.html
Purity
95.05
Solubility
DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
CN(CC1)CCN1C(C=C2)=CC=C2NC3=NC(S/C(C(N4)=O)=C\C5=CC=C([N+]([O-])=O)C=C5)=C4C=N3
Molecular Weight
489.55
References & Citations
[1]Targeting oncogenic STAT3 and STAT5 signaling with on 146040, a small molecule inhibitor of PI3K α/δ and BCR-ABL.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12338/ON-146040-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12338/ON-146040-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1404231-34-0
Available Sizes
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