AMACR Mouse Monoclonal Antibody [Clone ID: LBI5F10]
Product Specifications
Background
This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R) - and (S) -stereoisomers. The conversion to the (S) -stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]
Synonyms
AMACRD; CBAS4; RACE; RM
Gene Name
Alpha-methylacyl-CoA racemase
Gene ID
23600
UniProt
Q9UHK6
Conjugation
Unconjugated
Related Pathways
Metabolic pathways, Primary bile acid biosynthesis
Field of Research
Metabolic pathways, Primary bile acid biosynthesis
Concentration
1 mg/ml
Dilution
WB 1:2000, IHC 1:150
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
AMACR
Overview
AMACR mouse monoclonal antibody, clone LBI5F10
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=23600
Uniprot URL
https://www.uniprot.org/uniprot/Q9UHK6
Curated Selection
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