BCL10 Mouse Monoclonal Antibody [Clone ID: LBI4G4]
Product Specifications
Background
This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008]
Overview
BCL10 mouse monoclonal antibody, clone LBI4G4
Synonyms
C-E10; CARMEN; CIPER; CLAP; IMD37; mE10
Gene Name
B-cell CLL/lymphoma 10
Gene ID
8915
UniProt
O95999
Conjugation
Unconjugated
Related Pathways
B cell receptor signaling pathway, T cell receptor signaling pathway
Field of Research
B cell receptor signaling pathway, T cell receptor signaling pathway
Concentration
1 mg/ml
Dilution
WB 1:2000, IHC 1:150
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
BCL10
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=8915
Uniprot URL
https://www.uniprot.org/uniprot/O95999
Curated Selection
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