APE1 (APEX1) Mouse Monoclonal Antibody [Clone ID: LBI6E10]

Product Specifications

Background

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. [provided by RefSeq]

Overview

APEX1 mouse monoclonal antibody, clone LBI6E10

Synonyms

APE; APE1; APEN; APEX; APX; HAP1; REF1

Gene Name

Apurinic/apyrimidinic endodeoxyribonuclease 1

Gene ID

328

UniProt

P27695

Conjugation

Unconjugated

Related Pathways

Base excision repair

Field of Research

Base excision repair

Concentration

1 mg/ml

Dilution

WB 1:1000, IHC 1:150, IF 1:100, FLOW 1:100

Form

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome, Stem cell - Pluripotency, Transcription Factors

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.