SIRP alpha (SIRPA) Mouse Monoclonal Antibody [Clone ID: LBI1C6]
Product Specifications
Background
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]
Synonyms
BIT; CD172A; MFR; MYD-1; P84; PTPNS1; SHPS1; SIRP
Gene Name
Signal regulatory protein alpha
Gene ID
140885
UniProt
P78324
Conjugation
Unconjugated
Concentration
1 mg/ml
Dilution
WB 1:4000
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, Phosphatase, Transmembrane
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
SIRPA
Overview
SIRPA mouse monoclonal antibody, clone LBI1C6
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=140885
Uniprot URL
https://www.uniprot.org/uniprot/P78324
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
