IL6R Mouse Monoclonal Antibody [Clone ID: LBI2F4]
Product Specifications
Background
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, May 2011]
Synonyms
CD126; gp80; IL-6R-1; IL-6RA; IL6Q; IL6RA; IL6RQ
Gene Name
Interleukin 6 receptor
Gene ID
3570
UniProt
P08887
Conjugation
Unconjugated
Related Pathways
Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway
Field of Research
Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway
Concentration
1 mg/ml
Dilution
WB 1:4000, IHC 1:150, IF 1:100
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
IL6R
Overview
IL6R mouse monoclonal antibody, clone LBI2F4
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=3570
Uniprot URL
https://www.uniprot.org/uniprot/P08887
Curated Selection
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