P15 INK4b (CDKN2B) Mouse Monoclonal Antibody [Clone ID: LBI1H5]
Product Specifications
Background
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq]
Synonyms
CDK4I; INK4B; MTS2; P15; p15INK4b; TP15
Gene Name
Cyclin dependent kinase inhibitor 2B
Gene ID
1030
UniProt
P42772
Conjugation
Unconjugated
Related Pathways
Cell cycle, Pathways in cancer, Small cell lung cancer, TGF-beta signaling pathway
Field of Research
Cell cycle, Pathways in cancer, Small cell lung cancer, TGF-beta signaling pathway
Concentration
1 mg/ml
Dilution
WB 1:2000, FLOW 1:100
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
CDKN2B
Overview
CDKN2B (p15 INK4b) mouse monoclonal antibody, clone LBI1H5
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=1030
Uniprot URL
https://www.uniprot.org/uniprot/P42772
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
