Proteasome 20S beta 7 (PSMB7) Mouse Monoclonal Antibody [Clone ID: LBI1D1]
Product Specifications
Background
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. Expression of this catalytic subunit is downregulated by gamma interferon and proteolytic processing is required to generate a mature subunit. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit) . [provided by RefSeq]
Synonyms
Z
Gene Name
Proteasome 20S subunit beta 7
Gene ID
5695
UniProt
Q99436
Conjugation
Unconjugated
Related Pathways
Proteasome
Field of Research
Proteasome
Concentration
1.23 mg/ml
Dilution
WB 1:500~2000, IHC 1:150
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, Protease
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
PSMB7
Overview
PSMB7 (Proteasome 20S beta 7) mouse monoclonal antibody, clone LBI1D1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=5695
Uniprot URL
https://www.uniprot.org/uniprot/Q99436
Curated Selection
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