CCM2 Mouse Monoclonal Antibody [Clone ID: LBI1D1]
Product Specifications
Background
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms
C7orf22; OSM; PP10187
Gene Name
CCM2 scaffold protein
Gene ID
83605
UniProt
Q9BSQ5
Conjugation
Unconjugated
Concentration
0.87 mg/ml
Dilution
WB 1:2000
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
CCM2
Overview
CCM2 mouse monoclonal antibody, clone LBI1D1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=83605
Uniprot URL
https://www.uniprot.org/uniprot/Q9BSQ5
Curated Selection
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