RASSF1 Mouse Monoclonal Antibody [Clone ID: LBI3C2]
Product Specifications
Background
This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
Synonyms
123F2; NORE2A; RASSF1A; RDA32; REH3P21
Gene Name
Ras association domain family member 1
Gene ID
11186
UniProt
Q9NS23
Conjugation
Unconjugated
Related Pathways
Bladder cancer, Non-small cell lung cancer, Pathways in cancer
Field of Research
Bladder cancer, Non-small cell lung cancer, Pathways in cancer
Concentration
0.48 mg/ml
Dilution
WB 1:500, IF 1:100
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
RASSF1
Overview
RASSF1 mouse monoclonal antibody, clone LBI3C2
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=11186
Uniprot URL
https://www.uniprot.org/uniprot/Q9NS23
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