FADD Mouse Monoclonal Antibody [Clone ID: LBI1C11]
Product Specifications
Background
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq]
Synonyms
GIG3; MORT1
Gene Name
Fas associated via death domain
Gene ID
8772
UniProt
Q13158
Conjugation
Unconjugated
Related Pathways
Alzheimer's disease, Apoptosis, Pathways in cancer, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway
Field of Research
Alzheimer's disease, Apoptosis, Pathways in cancer, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway
Concentration
1 mg/ml
Dilution
WB 1:2000, FLOW 1:100
Form
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
FADD
Overview
Anti-FADD mouse monoclonal antibody, clone LBI1C11
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=8772
Uniprot URL
https://www.uniprot.org/uniprot/Q13158
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