Pyruvate Kinase (PKLR) Mouse Monoclonal Antibody [Clone ID: LBI1B4]
Product Specifications
Background
The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phohsphoenolpyruvate into pyruvate and ATP, which is the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are the common cause of chronic hereditary nonspherocytic hemolytic anemia (CNSHA or HNSHA) . Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Synonyms
PK1; PKL; PKR; PKRL; RPK
Gene Name
Pyruvate kinase L/R
Gene ID
5313
UniProt
P30613
Conjugation
Unconjugated
Related Pathways
Glycolysis / Gluconeogenesis, Insulin signaling pathway, Maturity onset diabetes of the young, Metabolic pathways, Purine metabolism, Pyruvate metabolism, Type II diabetes mellitus
Field of Research
Glycolysis / Gluconeogenesis, Insulin signaling pathway, Maturity onset diabetes of the young, Metabolic pathways, Purine metabolism, Pyruvate metabolism, Type II diabetes mellitus
Concentration
1 mg/ml
Dilution
WB 1:2000, FLOW 1:100
Form
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
PKLR
Overview
Anti-PKLR mouse monoclonal antibody, clone LBI1B4
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=5313
Uniprot URL
https://www.uniprot.org/uniprot/P30613
Curated Selection
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