Amyloid Precursor Protein (APP) Mouse Monoclonal Antibody [Clone ID: LBI3E3]
Product Specifications
Background
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy) . Multiple transcript variants encoding several different isoforms have been found for this gene.
Synonyms
AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2
Gene Name
Amyloid beta precursor protein
Gene ID
351
UniProt
P05067
Conjugation
Unconjugated
Related Pathways
Alzheimer's disease
Field of Research
Alzheimer's disease
Concentration
0.75 mg/ml
Dilution
WB 1:2000, IHC 1:50, IF 1:100, Flow 1:100
Form
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, Transmembrane
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
APP
Overview
Anti-APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone LBI3E3
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=351
Uniprot URL
https://www.uniprot.org/uniprot/P05067
Curated Selection
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