Amyloid Precursor Protein (APP) Mouse Monoclonal Antibody [Clone ID: LBI3D11]

Product Specifications

Background

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy) . Multiple transcript variants encoding several different isoforms have been found for this gene.

Overview

Anti-APP (Amyloid beta precursor protein) mouse monoclonal antibody, clone LBI3D11

Synonyms

AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2

Gene Name

Amyloid beta precursor protein

Gene ID

351

UniProt

P05067

Conjugation

Unconjugated

Related Pathways

Alzheimer's disease

Field of Research

Alzheimer's disease

Concentration

0.54 mg/ml

Dilution

WB 1:2000, IF 1:100, Flow 1:100

Form

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome, Transmembrane

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.