TPMT Mouse Monoclonal Antibody [Clone ID: LBI5B4]

Product Specifications

Background

This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q.

Overview

Anti-TPMT mouse monoclonal antibody, clone LBI5B4

Synonyms

OTTHUMP00000016076; S-adenosyl-L-methionine:thiopurine S-methyltransferase; thiopurine methyltransferase; thiopurine S-methyltransferase

Gene Name

Thiopurine S-methyltransferase

Gene ID

7172

UniProt

P51580

Conjugation

Unconjugated

Related Pathways

Drug metabolism - other enzymes

Field of Research

Drug metabolism - other enzymes

Concentration

0.6 mg/ml

Dilution

WB 1:1000, IHC 1:50

Form

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.