HIPPI (IFT57) Mouse Monoclonal Antibody [Clone ID: LBI4F6]
Product Specifications
Background
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity) . Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3'present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear
Synonyms
ESRRBL1; HIPPI; MHS4R2
Gene Name
Intraflagellar transport 57
Gene ID
55081
UniProt
Q9NWB7
Conjugation
Unconjugated
Related Pathways
Huntington's disease
Field of Research
Huntington's disease
Concentration
1 mg/ml
Dilution
WB 1:2000, IHC 1:50, IF 1:100
Form
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
IFT57
Overview
Anti-IFT57 (HIPPI) mouse monoclonal antibody, clone LBI4F6
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=55081
Uniprot URL
https://www.uniprot.org/uniprot/Q9NWB7
Curated Selection
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