HIPPI (IFT57) Mouse Monoclonal Antibody [Clone ID: LBI4F6]

Product Specifications

Background

Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity) . Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3'present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear

Overview

Anti-IFT57 (HIPPI) mouse monoclonal antibody, clone LBI4F6

Synonyms

ESRRBL1; HIPPI; MHS4R2

Gene Name

Intraflagellar transport 57

Gene ID

55081

UniProt

Q9NWB7

Conjugation

Unconjugated

Related Pathways

Huntington's disease

Field of Research

Huntington's disease

Concentration

1 mg/ml

Dilution

WB 1:2000, IHC 1:50, IF 1:100

Form

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.