XRCC1 Mouse Monoclonal Antibody [Clone ID: LBI2F8]

Product Specifications

Background

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Overview

Anti-XRCC1 mouse monoclonal antibody, clone LBI2F8

Synonyms

RCC

Gene Name

X-ray repair cross complementing 1

Gene ID

7515

UniProt

P18887

Conjugation

Unconjugated

Related Pathways

Base excision repair

Field of Research

Base excision repair

Concentration

0.64 mg/ml

Dilution

WB 1:2000, IHC 1:50, IF 1:100

Form

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.