L1CAM Mouse Monoclonal Antibody [Clone ID: LBI3G1]

Product Specifications

Background

The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus) . Alternative splicing of a neuron-specific exon is thought to be functionally relevant.

Overview

L1CAM mouse monoclonal antibody, clone LBI3G1

Synonyms

CAML1; CD171; HSAS; HSAS1; MASA; MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1

Gene Name

L1 cell adhesion molecule

Gene ID

3897

UniProt

P32004

Conjugation

Unconjugated

Related Pathways

Axon guidance, Cell adhesion molecules (CAMs)

Field of Research

Axon guidance, Cell adhesion molecules (CAMs)

Concentration

1 mg/ml

Dilution

WB 1:1000, IHC 1:50, IF 1:100, FLOW 1:100, IP 2-4ug/mg

Form

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.