L1CAM Mouse Monoclonal Antibody [Clone ID: LBI3G1]
Product Specifications
Background
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus) . Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
Synonyms
CAML1; CD171; HSAS; HSAS1; MASA; MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1
Gene Name
L1 cell adhesion molecule
Gene ID
3897
UniProt
P32004
Conjugation
Unconjugated
Related Pathways
Axon guidance, Cell adhesion molecules (CAMs)
Field of Research
Axon guidance, Cell adhesion molecules (CAMs)
Concentration
1 mg/ml
Dilution
WB 1:1000, IHC 1:50, IF 1:100, FLOW 1:100, IP 2-4ug/mg
Form
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
L1CAM
Overview
L1CAM mouse monoclonal antibody, clone LBI3G1
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=3897
Uniprot URL
https://www.uniprot.org/uniprot/P32004
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