FH Mouse Monoclonal Antibody [Clone ID: LBI9G4]
Product Specifications
Background
The protein encoded by this gene is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a cytosolic form and an N-terminal extended form, differing only in the translation start site used. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension generates the same form as in the cytoplasm. It is similar to some thermostable class II fumarases and functions as a homotetramer. Mutations in this gene can cause fumarase deficiency and lead to progressive encephalopathy. [provided by RefSeq]
Synonyms
FMRD; HLRCC; LRCC; MCL; MCUL1
Gene Name
Fumarate hydratase
Gene ID
2271
UniProt
P07954
Conjugation
Unconjugated
Related Pathways
Citrate cycle (TCA cycle), Metabolic pathways, Pathways in cancer, Renal cell carcinoma
Field of Research
Citrate cycle (TCA cycle), Metabolic pathways, Pathways in cancer, Renal cell carcinoma
Concentration
1 mg/ml
Dilution
WB 1:1000, IHC 1:50, IF 1:100, FLOW 1:100
Form
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
FH
Overview
FH mouse monoclonal antibody, clone LBI9G4
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=2271
Uniprot URL
https://www.uniprot.org/uniprot/P07954
Curated Selection
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