BubR1 (BUB1B) Mouse Monoclonal Antibody [Clone ID: LBI6E5]
Product Specifications
Background
This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.
Overview
Anti-BUB1B (BubR1) mouse monoclonal antibody, clone LBI6E5
Synonyms
Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1
Gene Name
BUB1 mitotic checkpoint serine/threonine kinase B
Gene ID
701
UniProt
O60566
Conjugation
Unconjugated
Related Pathways
Cell cycle
Field of Research
Cell cycle
Concentration
1 mg/ml
Dilution
WB: 1:200 - 1:1000, IHC 1:50, IF 1:100, Flow 1:100
Form
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, Protein Kinase, Stem cell - Pluripotency
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
BUB1B
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=701
Uniprot URL
https://www.uniprot.org/uniprot/O60566
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