BubR1 (BUB1B) Mouse Monoclonal Antibody [Clone ID: LBI15E11]

Product Specifications

Background

This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.

Overview

Anti-BUB1B (BubR1) mouse monoclonal antibody, clone LBI15E11

Synonyms

Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1

Gene Name

BUB1 mitotic checkpoint serine/threonine kinase B

Gene ID

701

UniProt

O60566

Conjugation

Unconjugated

Related Pathways

Cell cycle

Field of Research

Cell cycle

Concentration

1 mg/ml

Dilution

WB 1:2000 IHC 1:50 IF 1:100

Form

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome, Protein Kinase, Stem cell - Pluripotency

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.