TrkC (NTRK3) Mouse Monoclonal Antibody [Clone ID: LBI24B3]
Product Specifications
Background
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers.
Overview
Anti-NTRK3 (TrkC) mouse monoclonal antibody, clone LBI24B3
Synonyms
GP145-TrkC; TRKC; gp145 (trkC)
Gene Name
Neurotrophic receptor tyrosine kinase 3
Gene ID
4916
UniProt
Q16288
Conjugation
Unconjugated
Related Pathways
Neurotrophin signaling pathway
Field of Research
Neurotrophin signaling pathway
Concentration
0.9 mg/ml
Dilution
WB 1:2000, IHC 1:50
Form
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, Protein Kinase, Transmembrane
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
NTRK3
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=4916
Uniprot URL
https://www.uniprot.org/uniprot/Q16288
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