TRPM4 Mouse Monoclonal Antibody [Clone ID: LBI10H5]
Product Specifications
Background
Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca (2+), it is impermeable to it. Mediates transport of monovalent cations (Na (+) > K (+) > Cs (+) > Li (+) ), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca (2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca (2+) overload.
Synonyms
HTRPM4; LTrpC4; PFHB1B; TRPM4B
Gene Name
Transient receptor potential cation channel subfamily M member 4
Gene ID
54795
UniProt
Q8TD43
Conjugation
Unconjugated
Concentration
1 mg/ml
Dilution
WB 1:5000~10000, IHC 1:50
Form
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
TRPM4
Overview
TRPM4 mouse monoclonal antibody, clone LBI10H5
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=54795
Uniprot URL
https://www.uniprot.org/uniprot/Q8TD43
Curated Selection
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