TRPM4 Mouse Monoclonal Antibody [Clone ID: LBI14C3]

Product Specifications

Background

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca (2+), it is impermeable to it. Mediates transport of monovalent cations (Na (+) > K (+) > Cs (+) > Li (+) ), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca (2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca (2+) overload

Overview

Anti-TRPM4 mouse monoclonal antibody, clone LBI14C3

Synonyms

HTRPM4; LTrpC4; PFHB1B; TRPM4B

Gene Name

Transient receptor potential cation channel subfamily M member 4

Gene ID

54795

UniProt

Q8TD43

Conjugation

Unconjugated

Concentration

0.7 mg/ml

Dilution

WB 1:1000, IHC 1:50

Form

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.