Cardiac Troponin I (TNNI3) Mouse Monoclonal Antibody [Clone ID: LBI4E5]
Product Specifications
Background
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM) .
Overview
TNNI3 (Cardiac Troponin I) mouse monoclonal antibody, clone LBI4E5
Synonyms
CMD1FF; CMD2A; CMH7; cTnI; RCM1; TNNC1
Gene Name
Troponin I3, cardiac type
Gene ID
7137
UniProt
P19429
Conjugation
Unconjugated
Related Pathways
Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)
Field of Research
Cardiac muscle contraction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)
Concentration
1 mg/ml
Dilution
WB 1:2500~5000, IF 1:50~100
Form
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, ES Cell Differentiation/IPS, Stem cell - Pluripotency
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
TNNI3
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=7137
Uniprot URL
https://www.uniprot.org/uniprot/P19429
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