Sonic Hedgehog (SHH) Mouse Monoclonal Antibody [Clone ID: LBI10H6]
Product Specifications
Background
SHH is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo.
Synonyms
HHG1; HLP3; HPE3; MCOPCB5; SMMCI; TPT; TPTPS
Gene Name
Sonic hedgehog signaling molecule
Gene ID
6469
UniProt
Q15465
Conjugation
Unconjugated
Related Pathways
Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer
Field of Research
Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer
Concentration
1 mg/ml
Dilution
WB 1:1000~2000, IF 1:100
Form
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Buffer
PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Function
Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transmembrane
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Symbol
SHH
Overview
SHH (Sonic Hedgehog) mouse monoclonal antibody, clone LBI10H6
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=6469
Uniprot URL
https://www.uniprot.org/uniprot/Q15465
Curated Selection
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