PDX1 Mouse Monoclonal Antibody [Clone ID: LBI2A12]

Product Specifications

Background

Pdx1 is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. It is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in PDX1 gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4) .

Overview

Pdx1 mouse monoclonal antibody, clone LBI2A12

Synonyms

GSF; IDX-1; IPF1; IUF1; MODY4; PAGEN1; PDX-1; STF-1

Gene Name

Pancreatic and duodenal homeobox 1

Gene ID

3651

UniProt

P52945

Conjugation

Unconjugated

Related Pathways

Maturity onset diabetes of the young, Type II diabetes mellitus

Field of Research

Maturity onset diabetes of the young, Type II diabetes mellitus

Concentration

1 mg/ml

Dilution

WB 1:20000, IHC 1:50, IF 1:50~100

Form

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Buffer

PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Function

Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transcription Factors

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.