Phospho-Twist1-Y103 antibody [APR33671G]
Product Specifications
Background
Tissue Location: Subset of mesodermal cells.
Synonyms
Twist-related protein 1, Class A basic helix-loop-helix protein 38, bHLHa38, H-twist, TWIST1, BHLHA38, TWIST
Gene Name
TWIST1
Gene ID
7291
UniProt
Q15672
Chromosomal Location
Nucleus.
Applications
DB
Function
Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity) .
Molecular Weight
20954
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality phospho-Twist1-Y103 antibody [APR33671G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=7291
Uniprot URL
https://www.uniprot.org/uniprot/Q15672
Available Sizes
Curated Selection
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