GRB14 Antibody (N-Term) [APR33662G]
Product Specifications
Background
Tissue Location: Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle
Synonyms
Growth factor receptor-bound protein 14, GRB14 adapter protein, GRB14
Gene Name
GRB14
Gene ID
2888
UniProt
Q14449
Chromosomal Location
Cytoplasm. Endosome membrane; Peripheral membrane protein. Note=Upon insulin stimulation, translocates to the plasma membrane.
Applications
WB, FC, IF
Dilution
IF--1:25 FC--1:25 WB--1:1000
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Function
Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR) . Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.
Molecular Weight
60988
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality GRB14 Antibody (N-Term) [APR33662G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=2888
Uniprot URL
https://www.uniprot.org/uniprot/Q14449
Available Sizes
Curated Selection
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