GRB14 Antibody (N-Term) [APR33662G]

Product Specifications

Background

Tissue Location: Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality GRB14 Antibody (N-Term) [APR33662G].

Synonyms

Growth factor receptor-bound protein 14, GRB14 adapter protein, GRB14

Gene Name

GRB14

Gene ID

2888

UniProt

Q14449

Chromosomal Location

Cytoplasm. Endosome membrane; Peripheral membrane protein. Note=Upon insulin stimulation, translocates to the plasma membrane.

Applications

WB, FC, IF

Dilution

IF--1:25 FC--1:25 WB--1:1000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR) . Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal.

Molecular Weight

60988

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.