IFT57 Antibody (Center) [APR33647G]

Product Specifications

Background

Tissue Location: Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level)

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality IFT57 Antibody (Center) [APR33647G].

Synonyms

Intraflagellar transport protein 57 homolog, Dermal papilla-derived protein 8, Estrogen-related receptor beta-like protein 1, HIP1-interacting protein, MHS4R2, IFT57, DERP8, ESRRBL1, HIPPI

Gene Name

IFT57

Gene ID

55081

UniProt

Q9NWB7

Chromosomal Location

Cytoplasm, cytoskeleton, cilium basal body. Note=Concentrates within the inner segment of cilia

Applications

Dilution

WB--1:2000

Function

Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity) . Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'- AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.

Molecular Weight

49108

Storage Conditions

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.