NCR3 Antibody (N-Term) [APR33644G]
Product Specifications
Background
Tissue Location: Selectively expressed by all resting and activated NK cells and weakly expressed in spleen. {ECO:0000269|PubMed:10562324, ECO:0000269|Ref.2}
Synonyms
Natural cytotoxicity triggering receptor 3, Activating natural killer receptor p30, Natural killer cell p30-related protein, NK-p30, NKp30, CD337, NCR3, 1C7, LY117
Gene Name
NCR3
Gene ID
259197
UniProt
O14931
Chromosomal Location
Cell membrane; Single-pass type I membrane protein
Applications
WB
Dilution
WB--1:1000
Function
Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.
Molecular Weight
21593
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NCR3 Antibody (N-Term) [APR33644G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=259197
Uniprot URL
https://www.uniprot.org/uniprot/O14931
Available Sizes
Curated Selection
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