MYL2 Antibody (Center) [APR33591G]
Product Specifications
Synonyms
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform, MLC-2, MLC-2v, MYL2
Gene Name
HGNC:7583
Gene ID
4633
UniProt
P10916
Chromosomal Location
Cytoplasm, myofibril, sarcomere, A band {ECO:0000250|UniProtKB:P08733}
Applications
WB, FC, IHC-P-Leica
Dilution
IHC-P-Leica--1:1000 FC--1:25 IHC--1:250 WB--1:2000
Function
Contractile protein that plays a role in heart development and function (By similarity) . Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity) . During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity) .
Molecular Weight
18789
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MYL2 Antibody (Center) [APR33591G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=4633
Uniprot URL
https://www.uniprot.org/uniprot/P10916
Available Sizes
Curated Selection
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