H3f3b Antibody (Center) [APR33365G]
Product Specifications
Synonyms
Histone H33, H3f3a, H33a
Gene Name
H3-3a {ECO:0000250|UniProtKB:P84243}
Gene ID
15078;15081
UniProt
P84244
Chromosomal Location
Nucleus. Chromosome.
Applications
WB
Dilution
WB--1:2000
Function
Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Molecular Weight
15328
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality H3f3b Antibody (Center) [APR33365G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=15078;15081
Uniprot URL
https://www.uniprot.org/uniprot/P84244
Available Sizes
Curated Selection
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