IL11RA Antibody (C-term) [APR33321G]
Product Specifications
Background
Tissue Location: Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2 (PubMed:7670098) . Also expressed in normal and malignant prostate epithelial cell lines. Expression levels are increased in prostate carcinoma.
Synonyms
Interleukin-11 receptor subunit alpha, IL-11 receptor subunit alpha, IL-11R subunit alpha, IL-11R-alpha, IL-11RA, IL11RA
Gene Name
HGNC:5967
Gene ID
3590
UniProt
Q14626
Chromosomal Location
[Interleukin-11 receptor subunit alpha]: Membrane; Single-pass type I membrane protein [Isoform HCR2]: Secreted
Applications
WB
Dilution
WB--1:2000
Function
Receptor for interleukin-11 (IL11) . The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable) . Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.
Molecular Weight
45222
Storage Conditions
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality IL11RA Antibody (C-term) [APR33321G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=3590
Uniprot URL
https://www.uniprot.org/uniprot/Q14626
Available Sizes
Curated Selection
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