P27Kip1 (S10) Antibody [APR32775G]
Product Specifications
Background
Tissue Location: Expressed in all tissues tested. Highest levels in skeletal muscle, lowest in liver and kidney
Synonyms
Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1, CDKN1B, KIP1
Gene Name
CDKN1B
Gene ID
1027
UniProt
P46527
Chromosomal Location
Nucleus. Cytoplasm. Endosome. Note=Nuclear and cytoplasmic in quiescent cells. AKT- or RSK-mediated phosphorylation on Thr-198, binds 14-3-3, translocates to the cytoplasm and promotes cell cycle progression. Mitogen-activated UHMK1 phosphorylation on Ser-10 also results in translocation to the cytoplasm and cell cycle progression. Phosphorylation on Ser-10 facilitates nuclear export. Translocates to the nucleus on phosphorylation of Tyr-88 and Tyr-89. Colocalizes at the endosome with SNX6; this leads to lysosomal degradation (By similarity)
Applications
WB
Dilution
WB--1:1000
Function
28666995
Molecular Weight
22073
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality p27Kip1 (S10) Antibody [APR32775G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=1027
Uniprot URL
https://www.uniprot.org/uniprot/P46527
Available Sizes
Curated Selection
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