AMOTL2 Antibody (Center) [APR32609G]

Product Specifications

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality AMOTL2 Antibody (Center) [APR32609G].

Synonyms

Angiomotin-like protein 2, Leman coiled-coil protein, LCCP, AMOTL2, KIAA0989

Gene Name

AMOTL2

Gene ID

51421

UniProt

Q9Y2J4

Chromosomal Location

Recycling endosome.

Applications

Dilution

WB--1:2000

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC.