MEN1 Antibody (T594) [APR32434G]
Product Specifications
Background
Tissue Location: Ubiquitous.
Synonyms
Menin, MEN1, SCG2
Gene Name
MEN1
Gene ID
4221
UniProt
O00255
Chromosomal Location
Nucleus. Note=Concentrated in nuclear body-like structures. Relocates to the nuclear matrix upon gamma irradiation
Applications
WB, IHC-P, IF
Dilution
WB--1:1000 IHC-P--1:100~500 IF--1:10~50
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Function
Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4) . Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity) . May be involved in DNA repair.
Molecular Weight
68023
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MEN1 Antibody (T594) [APR32434G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=4221
Uniprot URL
https://www.uniprot.org/uniprot/O00255
Available Sizes
Curated Selection
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