BCOR Antibody (Center S1122) [APR32423G]

Product Specifications

Background

Tissue Location: Ubiquitously expressed.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality BCOR Antibody (Center S1122) [APR32423G].

Synonyms

BCL-6 corepressor, BCoR, BCOR, KIAA1575

Gene Name

BCOR

Gene ID

54880

UniProt

Q6W2J9

Chromosomal Location

Nucleus.

Applications

WB, IHC-P, FC

Dilution

WB--1:500

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Function

Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA- binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2) .