PTHLH Antibody (Center) [APR32418G]
Product Specifications
Background
Tissue Location: Ubiquitous. Also expressed in the mammary gland.
Synonyms
Parathyroid hormone-related protein, PTH-rP, PTHrP, Parathyroid hormone-like protein, PLP, PTHrP[1-36], PTHrP[38-94], Osteostatin, PTHrP[107-139], PTHLH, PTHRP
Gene Name
PTHLH
Gene ID
5744
UniProt
P12272
Chromosomal Location
Cytoplasm. Nucleus. Secreted.
Applications
WB, IHC-P, FC
Dilution
WB--1:1000 IHC-P--1:100~500 FC--1:10~50
Form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Function
Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity) . Promotes colon cancer cell migration and invasion in an integrin alpha-6/beta-1- dependent manner through activation of Rac1.
Molecular Weight
20194
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Overview
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PTHLH Antibody (Center) [APR32418G].
Gene ID URL
https://www.ncbi.nlm.nih.gov/gene/?term=5744
Uniprot URL
https://www.uniprot.org/uniprot/P12272
Available Sizes
Curated Selection
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