RFK Antibody (N-term) [APR32383G]

Product Specifications

Background

Tissue Location: Detected in brain, placenta and urinary bladder.

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality RFK Antibody (N-term) [APR32383G].

Synonyms

Riboflavin kinase, ATP:riboflavin 5'-phosphotransferase, Flavokinase, RFK

Gene Name

RFK

Gene ID

55312

UniProt

Q969G6

Chromosomal Location

Cytoplasm.

Applications

IHC-P, WB, FC

Dilution

IHC-P--1:100~500 WB--1:1000 FC--1:10~50

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Function

Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF- activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase.