What is the catalog number for FMR1 Antibody (N-term) [APR32346G]?

The catalog number for FMR1 Antibody (N-term) [APR32346G] is APR32346G.

What sizes are available for FMR1 Antibody (N-term) [APR32346G]?

FMR1 Antibody (N-term) [APR32346G] is available in the following size(s): 50 µL, 100 µL, 200 µL, 400 µL.

How many pack sizes does FMR1 Antibody (N-term) [APR32346G] come in?

FMR1 Antibody (N-term) [APR32346G] is available in 4 different pack sizes.

Is FMR1 Antibody (N-term) [APR32346G] in stock?

FMR1 Antibody (N-term) [APR32346G] is currently made to order / not held in immediate stock. Contact us for lead time.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.

Do you provide a Certificate of Analysis (CoA) for this product?

A Certificate of Analysis is available for most products upon request. Contact our support team with the lot number to obtain the relevant CoA.

FMR1 Antibody (N-term) [APR32346G]

Product Specifications

Background

Tissue Location: Expressed in the brain, cerebellum and testis (PubMed:8401578) . Also expressed in epithelial tissues (PubMed:8401578) . Expressed in mature oligodendrocytes (OLGs) (PubMed:23891804) . Expressed in fibroblast (PubMed:24204304) . Expressed in neurons, Purkinje cells and spermatogonias (at protein level) (PubMed:8401578) . Expressed in brain, testis and placenta (PubMed:8504300) . Expressed in neurons and lymphocytes (PubMed:8504300) .

Overview

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FMR1 Antibody (N-term) [APR32346G].

Synonyms

Fragile X mental retardation protein 1, FMRP, Protein FMR-1, FMR1

Gene Name

HGNC:3775

Gene ID

2332

UniProt

Q06787

Chromosomal Location

Nucleus. Nucleus, nucleolus. Chromosome, centromere {ECO:0000250|UniProtKB:P35922}. Chromosome {ECO:0000250|UniProtKB:P35922}. Cytoplasm. Cytoplasm, perinuclear region. Cytoplasm, Cytoplasmic ribonucleoprotein granule. Perikaryon. Cell projection, neuron projection. Cell projection, axon {ECO:0000250|UniProtKB:P35922}. Cell projection, dendrite {ECO:0000250|UniProtKB:P35922}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P35922}. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:P35922}. Cell projection, growth cone. Cell projection, filopodium tip {ECO:0000250|UniProtKB:P35922}. Cell junction, synapse {ECO:0000250|UniProtKB:P35922}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250|UniProtKB:P35922}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250|UniProtKB:P35922}. Cell membrane {ECO:0000250|UniProtKB:P35922}. Cytoplasm, Stress granule. Note=Colocalizes with H2AX/H2A.x in pericentromeric heterochromatin in response to DNA damaging agents (By similarity) . Localizes on meiotic pachytene-stage chromosomes (By similarity) . Forms nuclear foci representing sites of ongoing DNA replication in response to DNA damaging agents (By similarity) Shuttles between nucleus and cytoplasm in a XPO1/CRM1-dependent manner (PubMed:10196376) . Localizes to cytoplasmic ribonucleoprotein granules, also referred to as messenger ribonucleoprotein particles or mRNPs, along dendrites and dendritic spines (PubMed:9659908, PubMed:14532325) FMR1-containing cytoplasmic granules colocalize to F-actin-rich structures, including filopodium, spines and growth cone during the development of hippocampal neurons (By similarity) . FMR1-containing cytoplasmic granules are transported out of the soma along axon and dendrite to synaptic contacts in a microtubule- and kinesin-dependent manner (PubMed:12417734, PubMed:15380484) . Colocalizes with CACNA1B in the cytoplasm and at the cell membrane of neurons (By similarity) Colocalizes with CYFIP1, CYFIP2, NXF2 and ribosomes in the perinuclear region (By similarity) . Colocalizes with CYFIP1 and EIF4E in dendrites and probably at synapses (By similarity) . Colocalizes with FXR1, kinesin, 60S acidic ribosomal protein RPLP0 and SMN in cytoplasmic granules in the soma and neurite cell processes (PubMed:12417734, PubMed:18093976, PubMed:16636078) . Colocalizes with FXR1 and FXR2 in discrete granules, called fragile X granules (FXGs), along axon and presynaptic compartments (By similarity) . Colocalizes with TDRD3 in cytoplasmic stress granules (SGs) in response to various cellular stress (PubMed:18632687, PubMed:18664458, PubMed:16636078) {ECO:0000250|UniProtKB:P35922, ECO:0000250|UniProtKB:Q80WE1, ECO:0000269|PubMed:10196376, ECO:0000269|PubMed:12417734, ECO:0000269|PubMed:14532325, ECO:0000269|PubMed:15380484, ECO:0000269|PubMed:16636078, ECO:0000269|PubMed:18093976, ECO:0000269|PubMed:18632687, ECO:0000269|PubMed:18664458, ECO:0000269|PubMed:9659908} [Isoform 9]: Cytoplasm [Isoform 11]: Nucleus. Nucleus, Cajal body

Applications

IHC-P, WB, FC

Dilution

IHC-P--1:100~500 WB--1:1000 FC--1:10~50

Form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Function

1663137718653529191662692323582925464849186535291153294411157796125942142323582923891804147035741705736625464849170573661909799919166269769260111719189111577961259421417417632232358292444854823235829117191891857986825464849256922357692601115329441259421415282548186535291580546312927206191662691470357417057366189361627688265778159512950170153814198156595205121342556152024813610